Cannabidiol (CBD) – What We Know About It

Cannabidiol (CBD) is a natural compound found in the Cannabis plant. It has become increasingly popular over the last few years for its medicinal value and ability to help people with various conditions such as anxiety or neuropathic pain.

Cannabinoids like CBD work by interacting with our endocannabinoid system, including cannabinoid receptors that line up throughout the body and brain.

However, there is still much research needed on how exactly cannabinoids work. It should be noted that there is a lot of false information targeting people looking to buy CBD products.

This article aims to give information on what we know about CBD and what we don’t know about it. We will categorize the information into the following topics:

Cannabidiol (CBD) is one of many active cannabinoids identified in cannabis, but it is a significant constituent accounting for up to 40% of plant extracts. It has displayed sedative effects in animal tests. Other effects of CBD in the plant include anticonvulsant effects in animal models. Currently, there is no evidence that CBD will cause these or any other effect when it is administered to humans. It is widely believed that the reduced adverse effects of CBD when administered orally compared with THC are due to rapid absorption in the liver and transformation into inactive metabolites, such as 7-COOH-THC.

Pure CBD is a crystalline substance and has no smell or taste. The white powder, which results from its manufacture, is soluble in organic solvents and oils and very slightly soluble in water. It can be extracted from cannabis plants using high-proof spirits (often grain alcohol) to create a tincture, often referred to as RSHO™.

CBD can also be extracted from cannabis plants through supercritical CO2 extraction. The CBD hemp oil concentrate produced by this process is high in CBD and low in other natural plant molecules such as terpenes and cannabinoids, thus eliminating the THC. The supercritical CO2 extraction process allows for the use of cannabinoids and other plant molecules to be extracted from the raw material, thus giving full-spectrum CBD.

What People Use CBD For

Several clinical trials have been performed to determine the safety and effectiveness of CBD in different diseases.

The results from these studies have been encouraging, and we hope to see more in the future. However, as we mentioned before, there is still a lack of information on CBD’s effect on humans. Therefore, please do not try CBD as a cure for any disease without consulting your physician.

1) Acne

In this study, acne patients were treated with topical CBD gel for four weeks. The results showed a significant reduction in acne lesions after treatment with the CBD gel compared to placebo.

2) Schizophrenia

CBD has been shown to have a therapeutic effect on people with schizophrenia. Preliminary studies suggest that CBD may reduce psychotic symptoms such as agitation, distress, and insomnia.

3) Anxiety

There is some evidence that CBD could be an effective treatment of anxiety disorders such as generalized anxiety disorder (GAD) and post-traumatic stress disorder (PTSD). This study shows that CBD has anti-anxiety and antidepressant effects in an experimental model of neuropsychiatric diseases.

4) Sleep disorder

Patients suffering from sleep disorders have shown significantly improved quality of life after using CBD. This study shows that CBD may be effective for treating REM behavior disorder (RBD), a condition characterized by acting out during dreaming and REM sleep.

5) Diabetes

Some studies suggest that CBD has beneficial effects on people with diabetes. This study shows that CBD can reverse impaired glucose tolerance and insulin resistance.

6) Drug addiction

There is some evidence suggesting that CBD reduces the rewarding effects of morphine and heroin in animal models and reduces cue-induced craving in humans with a history of drug abuse.

7) Chronic pain

A survey conducted on patients suffering from chronic pain showed that most patients preferred using cannabis to treat their condition rather than opioid analgesics. This study shows that using CBD for seven days reduced chronic and neuropathic pain.

8) Depression

There is some evidence suggesting that CBD may be an effective treatment for depression. This open-label, one-case study found that the cannabis compound cannabidiol (CBD) effectively treated a patient with treatment-resistant depression.

9) Obsessive-compulsive disorder

A novel study has found that CBD significantly reduced the symptoms of obsessive-compulsive disorder (OCD) after three months of treatment. Another model of OCD used to test whether CBD would effectively reduce compulsive behavior showed promising results.

These studies show that CBD may be an effective treatment for many diseases, but more research still needs to be done to determine effectiveness for specific conditions.

As with any natural product, please consult your physician before using CBD as a form of alternative or integrative medicine.

Here are some of the effects of CBD:

  • Anti-emetic: Reduces nausea and vomiting. This study suggests that the cannabis compound CBD may represent a novel fast antidepressant drug with multiple mechanisms.
  • Anticonvulsant: Suppresses seizure activity. This animal study shows that CBD significantly reduces the development of epileptic seizures (temporal lobe epilepsy).
  • Anxiolytic: Reduces anxiety. This study shows that CBD may be effective in treating social anxiety disorder, which is characterized by fear and avoidance of social situations due to feelings of humiliation or embarrassment.
  • Antipsychotic: This slows the worsening of symptoms related to schizophrenia. A review of CBD studies found that CBD showed potential for treating psychosis and anxiety.
  • Adjunctive therapy: Used to enhance the effects of another medication. Current studies are looking at CBD combined with traditional medicines to treat epilepsy.
  • Antioxidant: Reduces free radicals that contribute to oxidative stress. Research suggests that CBD has strong antioxidant properties, which have benefits for slowing the aging process and preventing disease.
  • Anti-inflammatory: Reduces inflammation throughout the body. Research suggests that CBD has anti-inflammatory properties, making it an effective treatment for arthritis pain.
  • Antinociceptive: Activates pathways in your central nervous system involved in pain control to reduce feelings of pain. A study published in the Journal of Experimental Medicine found that CBD significantly suppressed rodents’ chronic inflammatory and neuropathic pain.
  • Neuroprotective: May protect cells from damage. CBD has been shown to have powerful antioxidant properties, which may help prevent neuronal damage and promote overall neuroplasticity and healthy brain function.
  • Appetite stimulant: Increases appetite.

What Is CBD Oil?

CBD oil is the major nonpsychoactive component of Cannabis sativa. According to a 2013 study published in the British Journal of Clinical Pharmacology, CBD benefits include acting in some experimental models as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic, and antipsychotic agent.

The ECS is responsible for setting the baseline activity levels of our immune system and nervous system, which then work to maintain our health. When the ECS falls out of whack, the systems regulated by it can begin to malfunction. CBD oil promotes the standard functionality of the ECS, which makes sure that you’ll have a healthy immune system and live a long, healthy life.

CBD oil has numerous effects on the brain and the body. Most research talks about how CBD affects your endocannabinoid system (ECS). The ECS regulates pain, sleep, mood, memory, appetite, and more.

What Are The Benefits Of Using CBD Oils?

There are many published studies regarding CBD, but here are the main benefits generally reported by people using CBD products:

  • Reduces anxiety
  • Reduces nausea and vomiting
  • Slows the worsening of symptoms related to schizophrenia
  • Reduces seizures in people with epilepsy
  • Suppresses muscle spasms in people with multiple sclerosis (MS)
  • Increases feelings of calmness and relaxation
  • It helps relieve chronic pain, inflammation, arthritis, and other physical ailments
  • It helps treat mental health disorders such as depression, anxiety, PTSD, and bipolar disorder

According to Healthline, hemp-derived CBD products (with less than 0.3% THC) are legal on the federal level but are still illegal under some state laws. Following is an overview of states where CBD is legal to some level.

Medical and Recreational Use

  • Alaska
  • Arizona
  • California
  • Colorado
  • Illinois
  • Maine
  • Massachusetts
  • Michigan
  • Montana
  • Nevada
  • New Jersey
  • Oregon
  • South Dakota
  • Vermont
  • Virginia
  • Washington
  • Washington D.C.

Medical Use Only

  • Arkansas
  • Connecticut
  • Delaware
  • Florida
  • Hawaii
  • Kansas
  • Louisiana
  • Maryland
  • Minnesota
  • Mississippi
  • Missouri
  • New Hampshire
  • New Mexico
  • New York
  • North Dakota
  • Ohio
  • Oklahoma
  • Texas
  • Utah
  • West Virginia

Specific Medical Issues

  • Alabama
  • Georgia
  • Idaho
  • Indiana
  • Iowa
  • Kentucky
  • South Carolina
  • Tennessee
  • Wisconsin
  • Wyoming